A/Prof. Mark M W Chong
Head, Genomics and Immunology Laboratory, St Vincent's Institute of Medical Research
Honorary Principal Research Fellow, Department of Medicine.

https://www.svi.edu.au/research_themes/genomics_and_immunology
https://orcid.org/0000-0002-3701-7397
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A/Prof Chong obtained his PhD from the University of Melbourne for research performed at the Walter and Eliza Hall Institute, followed by postdoctoral training at New York University in the United States.

A/Prof Chong's research team consists of a mixture of students (PhD, Masters, Honours and undergraduates), postdocs and research assistants working in two general research areas. Firstly, the Chong laboratory interested in gene regulatory mechanisms that control the development of immune cell subsets and how abnormalities in these mechanisms contribute to autoimmune disease. In particular, their research focuses on T lymphocyte development in the thymus and myeloid lineage development in the bone marrow. Secondly, the Chong laboratory is interested in non-coding RNAs, particularly microRNAs. Their research primarily focuses on how these RNAs are transcribed and processed in order to generate functional molecules.

A/Prof Chong is always on the look out for talented students, postdocs and research assistants to join his team.

Selected recent publications:

1. Koay, et al. (2016), Thymic precursors to the Mucosal-Associated Invariant T cell lineage, Nat Immunol, 17:1300.

2. Johanson, et al. (2015), Drosha controls dendritic cell development by cleavage of messenger RNAs encoding inhibitors of myelopoiesis, Nat Immunol, 16:1134.

3. Srivastava, et al. (2015), Roquin binds microRNA-146a and Argonaute 2 and regulates microRNA homeostasis, Nat Commun, 6:6253.

4. Knuckles, et al. (2012), Drosha regulates neurogenesis by controlling Neurogenin2 expression independent of microRNAs, Nat Neurosci, 15:962.

5. Kaneko, et al. (2011), DICER dysregulation induces cytotoxic Alu RNA accumulation in age-related macular degeneration, Nature, 471:325.

6. Collins, et al. (2011), RUNX-mediated association of Cd4 and Cd8 enables coordinate gene regulation, Immunity, 34:303.

7. Karginov, et al. (2010), Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha and additional nucleases, Mol Cell, 38:781.

8. Cheloufi, et al. (2010), A Dicer-independent miRNA biogenesis pathway that requires Argonaute catalysis, Nature, 465:584.

9. Chong, et al. (2010) Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells, Genes Dev, 24:659.

10. Chong et al. (2010), Canonical and alternate functions of the microRNA biogenesis machinery, Genes Dev, 24:1951.

Dr

Mark Chong

Honorary (Principal Fellow)

Department of Medicine

Dr

Mark Chong

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Division

Faculty of Medicine, Dentistry and Health Sciences

Primary Interest

Immunology

Dr

Mark Chong

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